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Chung “CS” Yang Ph.D.

Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Address William Levine Hall Room 129 160 Frelinghuysen Road Piscataway NJ 08854 Phone: 848-445-5360 Fax: 732-445-0687
Photo of Chung “CS” Yang Ph.D.

Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

  • Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
  • Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
  • Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
  • Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
  • Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

  • Conduct research as described above.
  • Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
  • Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
  • Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

  1. Zhao, G, Wu, X, Chen, P, Zhang, L, Yang, CS, Zhang, J. Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects. Free Radic. Biol. Med. 2018;126 :55-66. doi: 10.1016/j.freeradbiomed.2018.07.017. PubMed PMID:30056082
  2. Weng, MW, Lee, HW, Park, SH, Hu, Y, Wang, HT, Chen, LC, Rom, WN, Huang, WC, Lepor, H, Wu, XR et al.. Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (27):E6152-E6161. doi: 10.1073/pnas.1804869115. PubMed PMID:29915082
  3. Bak, MJ, Furmanski, P, Shan, NL, Lee, HJ, Bao, C, Lin, Y, Shih, WJ, Yang, CS, Suh, N. Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer. Carcinogenesis. 2018; :. doi: 10.1093/carcin/bgy071. PubMed PMID:29846560 PubMed Central PMC6067126
  4. Dai, Z, Feng, S, Liu, A, Wang, H, Zeng, X, Yang, CS. Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice. Food Res. Int. 2018;109 :350-357. doi: 10.1016/j.foodres.2018.04.054. PubMed PMID:29803460 PubMed Central PMC5976246
  5. Liu, AB, Tao, S, Lee, MJ, Hu, Q, Meng, X, Lin, Y, Yang, CS. Effects of gut microbiota and time of treatment on tissue levels of green tea polyphenols in mice. Biofactors. 2018; :. doi: 10.1002/biof.1430. PubMed PMID:29740891
  6. Yang, H, Xu, M, Lu, F, Zhang, Q, Feng, Y, Yang, CS, Li, N, Jia, X. Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation. Oncogene. 2018;37 (29):3909-3923. doi: 10.1038/s41388-018-0246-8. PubMed PMID:29662196
  7. Feng, S, Gan, L, Yang, CS, Liu, AB, Lu, W, Shao, P, Dai, Z, Sun, P, Luo, Z. Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. J. Agric. Food Chem. 2018;66 (13):3417-3425. doi: 10.1021/acs.jafc.7b06146. PubMed PMID:29583004
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Categories: Faculty, Toxicology

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