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Chung “CS” Yang Ph.D.

Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 129 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-5360 Work Fax: 732-445-0687
Photo of Chung “CS” Yang Ph.D.

Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

  • Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
  • Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
  • Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
  • Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
  • Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

  • Conduct research as described above.
  • Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
  • Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
  • Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

  1. Huang, HB, Yang, SB, Shen, LJ, Lv, QW, Guo, M, Zhou, J, Li, Z, Yang, CS, Wang, LY, Zhang, H et al.. A prospective study on serum secreted protein acidic and rich in cysteine-like 1 as a prognostic marker for severe traumatic brain injury. Clin. Chim. Acta. 2019;491 :19-23. doi: 10.1016/j.cca.2019.01.005. PubMed PMID:30639238
  2. Ren, N, Kim, E, Li, B, Pan, H, Tong, T, Yang, CS, Tu, Y. Flavonoids alleviating insulin resistance through inhibition of inflammatory signaling. J. Agric. Food Chem. 2019; :. doi: 10.1021/acs.jafc.8b05348. PubMed PMID:30612424
  3. Dworak, N, Makosa, D, Chatterjee, M, Jividen, K, Yang, CS, Snow, C, Simke, WC, Johnson, IG, Kelley, JB, Paschal, BM et al.. A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Aging Cell. 2018; :e12851. doi: 10.1111/acel.12851. PubMed PMID:30565836
  4. Yang, CS, Zhang, J. Studies on the Prevention of Cancer and Cardiometabolic Diseases by Tea: Issues on Mechanisms, Effective Doses and Toxicities. J. Agric. Food Chem. 2018; :. doi: 10.1021/acs.jafc.8b05242. PubMed PMID:30541286
  5. Kim, YR, Yang, CS. Protective roles of ginseng against bacterial infection. Microb Cell. 2018;5 (11):472-481. doi: 10.15698/mic2018.11.654. PubMed PMID:30483519 PubMed Central PMC6244293
  6. Yang, CS, Zhang, QX, Chang, SH, Zhang, LJ, Li, LM, Qi, Y, Wang, J, Sun, ZH, Zhangning, N, Yang, L et al.. Neuromyelitis optica spectrum disorders with and without connective tissue disorders. BMC Neurol. 2018;18 (1):177. doi: 10.1186/s12883-018-1182-5. PubMed PMID:30355349 PubMed Central PMC6199722
  7. Wang, RC, Sakata, S, Chen, BJ, Chang, ST, Hsieh, PP, Yang, CS, Baba, S, Takeuchi, K, Chuang, SS. Mycosis fungoides in Taiwan shows a relatively high frequency of large cell transformation and CD56 expression. Pathology. 2018;50 (7):718-724. doi: 10.1016/j.pathol.2018.08.008. PubMed PMID:30348505
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Categories: Faculty, Toxicology
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