< Chung “CS” Yang Ph.D. EOHSI Directory | EOHSI

Chung “CS” Yang Ph.D. » EOHSI Directory


Chung “CS” Yang Ph.D.

Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Address William Levine Hall Room 129 160 Frelinghuysen Road Piscataway NJ 08854 Phone: 848-445-5360 Fax: 732-445-0687
Photo of Chung “CS” Yang Ph.D.

Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

  • Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
  • Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
  • Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
  • Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
  • Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

  • Conduct research as described above.
  • Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
  • Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
  • Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

  1. Lee, MJ, Feng, W, Yang, L, Chen, YK, Chi, E, Liu, A, Yang, CS. Methods for efficient analysis of tocopherols, tocotrienols and their metabolites in animal samples with HPLC-EC. J Food Drug Anal. 2018;26 (1):318-329. doi: 10.1016/j.jfda.2017.07.012. PubMed PMID:29389570
  2. Huang, J, Feng, S, Liu, A, Dai, Z, Wang, H, Reuhl, K, Lu, W, Yang, CS. Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice. Mol Nutr Food Res. 2018;62 (4):. doi: 10.1002/mnfr.201700696. PubMed PMID:29278293
  3. Wang, H, Yang, X, Liu, A, Wang, G, Bosland, MC, Yang, CS. δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice. Carcinogenesis. 2018;39 (2):158-169. doi: 10.1093/carcin/bgx128. PubMed PMID:29121168
  4. Feng, S, Dai, Z, Liu, A, Wang, H, Chen, J, Luo, Z, Yang, CS. β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet. Food Funct. 2017;8 (11):4179-4186. doi: 10.1039/c7fo00375g. PubMed PMID:29034917
  5. Zhang, K, Dong, R, Sun, K, Wang, X, Wang, J, Yang, CS, Zhang, J. Synergistic toxicity of epigallocatechin-3-gallate and diethyldithiocarbamate, a lethal encounter involving redox-active copper. Free Radic. Biol. Med. 2017;113 :143-156. doi: 10.1016/j.freeradbiomed.2017.09.027. PubMed PMID:28974447
  6. Das Gupta, S, Patel, M, Wahler, J, Bak, MJ, Wall, B, Lee, MJ, Lin, Y, Shih, WJ, Cai, L, Yang, CS et al.. Differential Gene Regulation and Tumor-Inhibitory Activities of Alpha-, Delta-, and Gamma-Tocopherols in Estrogen-Mediated Mammary Carcinogenesis. Cancer Prev Res (Phila). 2017;10 (12):694-703. doi: 10.1158/1940-6207.CAPR-17-0190. PubMed PMID:28972008
  7. Samavat, H, Ursin, G, Emory, TH, Lee, E, Wang, R, Torkelson, CJ, Dostal, AM, Swenson, K, Le, CT, Yang, CS et al.. A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer. Cancer Prev Res (Phila). 2017;10 (12):710-718. doi: 10.1158/1940-6207.CAPR-17-0187. PubMed PMID:28904061
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Categories: Faculty, Toxicology

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