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Chung “CS” Yang Ph.D.

Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 129 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-5360 Work Fax: 732-445-0687
Photo of Chung “CS” Yang Ph.D.

Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

  • Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
  • Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
  • Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
  • Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
  • Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

  • Conduct research as described above.
  • Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
  • Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
  • Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

  1. Huang, HT, Tsai, SF, Wu, HT, Huang, HY, Hsieh, HH, Kuo, YM, Chen, PS, Yang, CS, Tzeng, SF. Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus. BMC Neurosci. 2019;20 (1):33. doi: 10.1186/s12868-019-0516-6. PubMed PMID:31291887
  2. D'Agostino, L, Nie, Y, Goswami, S, Tong, K, Yu, S, Bandyopadhyay, S, Flores, J, Zhang, X, Balasubramanian, I, Joseph, I et al.. Recycling endosomes in mature epithelia restrain tumorigenic signaling. Cancer Res. 2019; :. doi: 10.1158/0008-5472.CAN-18-4075. PubMed PMID:31239271
  3. Liao, CY, Yang, CS, Chen, YJ. "Low- fat" pseudoangiomatous spindle cell lipoma. Int. J. Dermatol. 2019; :. doi: 10.1111/ijd.14514. PubMed PMID:31187478
  4. Dai, Z, Feng, S, Liu, AB, Wang, H, Zeng, X, Yang, CS. Protective effects of α-galacto-oligosaccharides against a high-fat/western-style diet-induced metabolic abnormalities in mice. Food Funct. 2019;10 (6):3660-3670. doi: 10.1039/c9fo00463g. PubMed PMID:31166330 PubMed Central PMC6588291
  5. Yu, SJ, Wang, YC, Chang, CY, Hsieh, W, Chen, S, Yang, CS, Lin, SZ, Wang, Y. NanoCsA improves the survival of human iPSC transplant in hemiparkinsonian rats. Brain Res. 2019;1719 :124-132. doi: 10.1016/j.brainres.2019.05.040. PubMed PMID:31153914
  6. Li, D, Wang, R, Huang, J, Cai, Q, Yang, CS, Wan, X, Xie, Z. Effects and Mechanisms of Tea Regulating Blood Pressure: Evidences and Promises. Nutrients. 2019;11 (5):. doi: 10.3390/nu11051115. PubMed PMID:31109113 PubMed Central PMC6567086
  7. Kamimura, Y, Yang, CS, Lee, CY. Fitness advantages of the biased use of paired laterally symmetrical penises in an insect. J. Evol. Biol. 2019; :. doi: 10.1111/jeb.13486. PubMed PMID:31081978
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Categories: Faculty, Toxicology
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