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Chung “CS” Yang Ph.D.

Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 129 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-5360 Work Fax: 732-445-0687
Photo of Chung “CS” Yang Ph.D.

Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

  • Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
  • Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
  • Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
  • Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
  • Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

  • Conduct research as described above.
  • Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
  • Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
  • Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

  1. Zhang, C, Zhang, M, Qiu, W, Ma, H, Zhang, X, Zhu, Z, Yang, CS, Jia, D, Zhang, TX, Yuan, M et al.. Safety and efficacy of tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder (TANGO): an open-label, multicentre, randomised, phase 2 trial. Lancet Neurol. 2020;19 (5):391-401. doi: 10.1016/S1474-4422(20)30070-3. PubMed PMID:32333897
  2. Haw, YL, Yu, TC, Yang, CS. A CARE-compliant article: a case report of possible association between recurrence of multiple evanescent white dot syndrome and the Herpesviridae family. Medicine (Baltimore). 2020;99 (15):e19794. doi: 10.1097/MD.0000000000019794. PubMed PMID:32282743
  3. Hanh, BTB, Park, JW, Kim, TH, Kim, JS, Yang, CS, Jang, K, Cui, J, Oh, DC, Jang, J. Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent. Molecules. 2020;25 (7):. doi: 10.3390/molecules25071597. PubMed PMID:32244387 PubMed Central PMC7181020
  4. Zhou, J, Yang, CS, Shen, LJ, Lv, QW, Xu, QC. Usefulness of serum glucose and potassium ratio as a predictor for 30-day death among patients with severe traumatic brain injury. Clin. Chim. Acta. 2020;506 :166-171. doi: 10.1016/j.cca.2020.03.039. PubMed PMID:32240656
  5. Lee, D, Kim, YR, Kim, JS, Kim, D, Kim, S, Kim, SY, Jang, K, Lee, JD, Yang, CS. Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice. Arch. Pharm. Res. 2020;43 (4):449-461. doi: 10.1007/s12272-020-01231-4. PubMed PMID:32236798
  6. Khan, MS, Kim, JS, Hwang, J, Choi, Y, Lee, K, Kwon, Y, Jang, J, Yoon, S, Yang, CS, Choi, J et al.. Effective delivery of mycophenolic acid by oxygen nanobubbles for modulating immunosuppression. Theranostics. 2020;10 (9):3892-3904. doi: 10.7150/thno.41850. PubMed PMID:32226527 PubMed Central PMC7086369
  7. Kim, YR, Kim, JS, Gu, SJ, Jo, S, Kim, S, Young Kim, S, Lee, D, Jang, K, Choo, H, Kim, TH et al.. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10 (1):4570. doi: 10.1038/s41598-020-61630-x. PubMed PMID:32165681 PubMed Central PMC7067850
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Categories: Faculty, Toxicology
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