Mingzhu Fang, MD, PhD, DABT

Assistant Professor Rutgers -School of Public HealthEOHSI – Toxicology
Work EOHSI Room 412 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-3720 (Office) Work Phone: 848-445-0216 (Lab) Work Fax: 732-445-4161
Photo of Mingzhu Fang MD, PhD, DABT

Biographical Info

Dr. Fang is an Assistant Professor at the Department of Environmental & Occupational Health in the School of Public Health at Rutgers University. She obtained her M.D. in Clinical Medicine in 1987 and a M.S. in Pathology in 1990 from Norman Bethune Medical School at Jilin University in China. She received her Ph.D. in Toxicology from Seoul National University of South Korea in 2000, as well as post-doctoral training in School of Pharmacy at Rutgers University in 2004. Recently (2014), she is recognized as a Diplomate of the American Board of Toxicology (D.A.B.T.).

Research Areas

Dr. Fang’s research focuses on genetic and epigenetic mechanisms in carcinogenesis and chemoprevention. She has been studying epigenetic chemopreventive activities of dietary compounds (e.g. tea polyphenols and methylselenocysteine). Recently, she is interested in epigenetic regulation of circadian rhythm in carcinogenesis and chemoprevention of breast cancer, biomarker discovery of circadian disruption, and intervention strategy development for shift workers

Scholarly Activities

  • 2018 Distinguished Chinese Toxicologist Lectureship Award, AACT/SOT
  • 2017 NIH/NIEHS R21 Award
  • 2013 International Collaboration Award from S. Korea
  • 2012 NJ Health Foundation, Seed Grant
  • 2012 SOT Colgate-Palmolive Grant for Alternative Research
  • 2010 NIEHS CEED Career Development Award
  • 2004 Annual Bibliography of Significant Advances in Dietary Supplements Research by ODS, NIH
  • 2003 Honored on the Cover of Cancer Res
  • 2003 Gallo Award in 2003 Annual Retreat on Cancer Research in New Jersey (ARCRNJ)
  • 2002 The New Jersey Cancer Research Award for Scientific Excellence, 2002 ARCRNJ
  • 2000 Yong Investigator Award, Asian Society of Toxicology, 2000 ASIATOX II

Recent Publications

  1. Shan, NL, Minden, A, Furmanski, P, Bak, MJ, Cai, L, Wernyj, R, Sargsyan, D, Cheng, D, Wu, R, Kuo, HD et al.. Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds. Cancer Prev Res (Phila). 2020;13 (8):673-686. doi: 10.1158/1940-6207.CAPR-19-0566. PubMed PMID:32467291 PubMed Central PMC7415686
  2. Yang, Y, Yang, I, Cao, M, Su, ZY, Wu, R, Guo, Y, Fang, M, Kong, AN. Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells. AAPS J. 2018;20 (2):32. doi: 10.1208/s12248-018-0197-6. PubMed PMID:29603113 PubMed Central PMC6286093
  3. Guo, Y, Wu, R, Gaspar, JM, Sargsyan, D, Su, ZY, Zhang, C, Gao, L, Cheng, D, Li, W, Wang, C et al.. DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis. 2018;39 (5):669-680. doi: 10.1093/carcin/bgy043. PubMed PMID:29547900 PubMed Central PMC6248359
  4. Fang, M, Kang, HG, Park, Y, Estrella, B, Zarbl, H. In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells. J Vis Exp. 2017; (127):. doi: 10.3791/55832. PubMed PMID:28994762 PubMed Central PMC5752347
  5. Fang, M, Ohman Strickland, PA, Kang, HG, Zarbl, H. Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis. Oncotarget. 2017;8 (20):32752-32768. doi: 10.18632/oncotarget.15678. PubMed PMID:28427145 PubMed Central PMC5464825
  6. Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp Mol Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
  7. Fang, M, Guo, WR, Park, Y, Kang, HG, Zarbl, H. Enhancement of NAD⁺-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. Oncotarget. 2015;6 (40):42879-91. doi: 10.18632/oncotarget.6002. PubMed PMID:26544624 PubMed Central PMC4767478
  8. Yang, CS, Fang, M, Lambert, JD, Yan, P, Huang, TH. Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds. Nutr Rev. 2008;66 Suppl 1 :S18-20. doi: 10.1111/j.1753-4887.2008.00059.x. PubMed PMID:18673481 PubMed Central PMC2829855
  9. Fang, M, Chen, D, Yang, CS. Dietary polyphenols may affect DNA methylation. J Nutr. 2007;137 (1 Suppl):223S-228S. doi: 10.1093/jn/137.1.223S. PubMed PMID:17182830
  10. Li, N, Sood, S, Wang, S, Fang, M, Wang, P, Sun, Z, Yang, CS, Chen, X. Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res. 2005;11 (5):2089-96. doi: 10.1158/1078-0432.CCR-04-1684. PubMed PMID:15756036
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Complete List of Her Published Work Can be found in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47350630/?sort=date&direction=ascending


Categories: Faculty, Toxicology

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