George C Wagner, Ph.D.

Professor Rutgers University, School of Arts and SciencesEOHSI – Toxicology
Work Psychology Building Room 229 152 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-4660
Photo of George C Wagner Ph.D.

Biographical Info

Research Areas

  • Using an animal model of autism, the deleterious effects of early toxicant exposure are assessed in mice as they develop. In particular, the maturation of social, cognitive, and motor skills are assessed following early administration of toxicants.
  • Behavioral Toxicology and Animal Models of Parkinson`s disease and autism

Research Highlights

  • Developed an animal model of autism to assess gene by toxicant interactions resulting in behavioral deficits in mice

Scholarly Activities

  • 2006 NJ Biomedical Research Association Mentor Award
  • 1994 Warren L. Susman Teaching Excellence Award, Rutgers University

Recent Publications

  1. Gifford, JJ, Deshpande, P, Mehta, P, Wagner, GC, Kusnecov, AW. The Effect of Valproic Acid Exposure throughout Development on Microglia Number in the Prefrontal Cortex, Hippocampus and Cerebellum. Neuroscience. 2022;481 :166-177. doi: 10.1016/j.neuroscience.2021.11.012. PubMed PMID:34780921
  2. Gifford, JJ, Wagner, GC. The effect of ascorbic acid pretreatment on amphetamine-induced dopamine depletion in male and female mice. Neuroreport. 2020;31 (10):737-740. doi: 10.1097/WNR.0000000000001474. PubMed PMID:32459674
  3. Gifford, JJ, Norton, SA, Kusnecov, AW, Wagner, GC. Valproic acid induces nuclear factor erythroid 2-related factor 2 expression in fetal and neonatal brains but not in adult brain: evidence of the gamma-aminobutyric acid-shift hypothesis. Neuroreport. 2020;31 (6):433-436. doi: 10.1097/WNR.0000000000001421. PubMed PMID:32168103
  4. Norton, SA, Gifford, JJ, Pawlak, AP, Derbaly, A, Sherman, SL, Zhang, H, Wagner, GC, Kusnecov, AW. Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment. Neuroscience. 2020;434 :8-21. doi: 10.1016/j.neuroscience.2020.02.029. PubMed PMID:32112916
  5. Francis, NL, Zhao, N, Calvelli, HR, Saini, A, Gifford, JJ, Wagner, GC, Cohen, RI, Pang, ZP, Moghe, PV. Peptide-Based Scaffolds for the Culture and Transplantation of Human Dopaminergic Neurons. Tissue Eng Part A. 2020;26 (3-4):193-205. doi: 10.1089/ten.TEA.2019.0094. PubMed PMID:31537172 PubMed Central PMC7044800
  6. Gergues, MM, Moiseyenko, A, Saad, SZ, Kong, AN, Wagner, GC. Nrf2 deletion results in impaired performance in memory tasks and hyperactivity in mature and aged mice. Brain Res. 2018;1701 :103-111. doi: 10.1016/j.brainres.2018.08.033. PubMed PMID:30194014 PubMed Central PMC8111504
  7. Hershey, JD, Gifford, JJ, Zizza, LJ, Pavlenko, DA, Wagner, GC, Miller, S. Effects of Various Cleaning Agents on the Performance of Mice in Behavioral Assays of Anxiety. J Am Assoc Lab Anim Sci. 2018;57 (4):335-339. doi: 10.30802/AALAS-JAALAS-17-000161. PubMed PMID:29950249 PubMed Central PMC6059223
  8. Sheleg, M, Yochum, CL, Richardson, JR, Wagner, GC, Zhou, R. Corrigendum to “Ephrin-A5 regulates inter-male aggression in mice” [Behav. Brain Res. 286 (June) (2015) 300-307]. Behav Brain Res. 2017;335 :223. doi: 10.1016/j.bbr.2017.08.019. PubMed PMID:28827072
  9. Mamiya, PC, Matray-Devoti, J, Fisher, H, Wagner, GC. Mice increased target biting behaviors 24h after co-administration of alcohol and fluoxetine. Brain Res. 2017;1662 :110-115. doi: 10.1016/j.brainres.2017.02.007. PubMed PMID:28193480
  10. Sheleg, M, Yochum, CL, Richardson, JR, Wagner, GC, Zhou, R. Ephrin-A5 regulates inter-male aggression in mice. Behav Brain Res. 2015;286 :300-7. doi: 10.1016/j.bbr.2015.03.001. PubMed PMID:25746458 PubMed Central PMC4390541
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Categories: Faculty, Toxicology, Member, Tox Member

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