Guofeng You, Ph.D.
William Levine Hall, Room 218
Ernest Mario School of Pharmacy
160 Frelinghuysen Road
Piscataway, NJ 08854
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You's research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
2012 NIH Review Panel for COBRE Pilot Project Applications
2012 NIH Special Emphasis Review Panel for Program Project Grants.
2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
2011 NIH Special Emphasis Review Panel for Program Project Grants.
2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
2006-present Editorial Board, Pharmaceutical Research