The scientific goals of this Core are to understand the impact of environmental factors on chemical toxicity by studying the biotransformation of environmental chemicals and molecular mechanisms of their toxicities, including carcinogenesis and disruption of endocrine systems.  Understanding the carcinogenic processes and the chemoprevention of carcinogenesis and toxicity are also important goals of this Core.

We meet almost every Monday 12:00 noon to 1:00 p.m. in EOHSI Rm. 402 to discuss our research and to hear presentations from EHS center members as well as those outside the Center.  These meetings are advertised as “Monday Lunch Discussions”, to facilitate good attendance by all those interested.  Cores II and III  have jointly sponsor some of these meetings so as to facilitate sharing of information and to facilitate interaction and collaboration. These topics include diverse issues related to environmental chemicals and their effects on human health. The speaker/discussion leader and title are widely distributed by E-mail and notices posted on the building bulletin boards. These meeting are popular in the Center resulting in enhanced sharing of ideas and increased inter-core and intra-core collaborations.  Three meetings a year are set aside to cover Core I business issues such as directions of research, exploring new opportunities for research, the election and/or removal of members, etc. and the attendance at these are restricted to Core I members.