Yoke-Chen Chang Ph.D.Assistant Research Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
- BS, National Chung-Hsing University, Taichung, Taiwan
- MS, Rutgers University, New Brunswick, NJ
- PhD, Rutgers University, New Bruswick, NJ
- Post-Doc, UMDNJ/Rutgers University, Piscataway, NJ
My primary research area in my lab involves research involving the vesicating agent, sulfur mustard (SM). There are two basic sides to the research. The first is a basic research aspect that involves elucidating the mechanism of action of the SM. In this capacity, we are looking at the direct effect of SM on protein-protein interactions of molecules known to stabilize the skin structural integrity (eg various laminins, collagens, and their integrin receptors). We are also looking at the effects of SM on keratinocyte adhesion and migration with in vitro assays. We also have an applied research program that involves an in vivo mouse ear vesicant model. We use this model to test potential therapeutic countermeasure agents against SM-induced skin injury. We use various histological, wound repair, and gene profile analysis assays to evaluate these compounds.
- 2009, 2010, 2013: American Association of Anatomists (AAA) Young Faculty Travel Award, FASEB/EB
- 2015: Best Paper of the Year Award, Society of Toxicology Annual Meeting, Dermal Specialty Section
- 2008: Junior Investigator CounterACT Travel Award at the 2nd Annual CounterACT Network Research Symposium, Washington D.C.
- 2009: American Association of Anatomists (AAA) Young Faculty Travel Award, FASEB meeting, New Orleans.
- DeSantis-Rodrigues, A, Chang, YC, Hahn, RA, Po, IP, Zhou, P, Lacey, CJ, Pillai, A, C Young, S, Flowers, RA 2nd, Gallo, MA et al.. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest. Ophthalmol. Vis. Sci. 2016;57 (4):1687-98. doi: 10.1167/iovs.15-17269. PubMed PMID:27058125 PubMed Central PMC4829087
- Chang, YC, Wang, JD, Hahn, RA, Gordon, MK, Joseph, LB, Heck, DE, Heindel, ND, Young, SC, Sinko, PJ, Casillas, RP et al.. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol. Appl. Pharmacol. 2014;280 (2):236-44. doi: 10.1016/j.taap.2014.07.016. PubMed PMID:25127551 PubMed Central PMC4254337
- Chang, YC, Wang, JD, Svoboda, KK, Casillas, RP, Laskin, JD, Gordon, MK, Gerecke, DR. Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol. Appl. Pharmacol. 2013;268 (2):178-87. doi: 10.1016/j.taap.2013.01.014. PubMed PMID:23357548 PubMed Central PMC3768256
- Chang, YC, Sabourin, CL, Lu, SE, Sasaki, T, Svoboda, KK, Gordon, MK, Riley, DJ, Casillas, RP, Gerecke, DR. Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J. Biochem. Mol. Toxicol. ;23 (3):172-84. doi: 10.1002/jbt.20275. PubMed PMID:19526566 PubMed Central PMC4465420
- Gerecke, DR, Chen, M, Isukapalli, SS, Gordon, MK, Chang, YC, Tong, W, Androulakis, IP, Georgopoulos, PG. Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol. Appl. Pharmacol. 2009;234 (2):156-65. doi: 10.1016/j.taap.2008.09.020. PubMed PMID:18955075 PubMed Central PMC3066660