EOHSI

Research Areas

The Zhou laboratory is interested in the mechanisms mediating cell-cell communication and their roles in normal development, physiology, and diseases. Specifically the Zhou laboratory is investigating the functions of a large family of tyrosine kinase receptors, the Ephs, and their ligands, the ephrins, in neural circuit formation, eye development, and behavior regulations including motor activity, circadian rhythm, and aggression. The Zhou laboratory employs both in vitro and in vivo techniques, including neuron cultures, transgenic and knockout mice, as well as behavior assays.

Research Highlights

Demonstration of a repulsive function of ephrins in axon guidance

Discovering signal transduction pathways mediating ephrin-induced growth cone guidance

Establishing a novel cataract mouse model

Elucidating regulation of cell-cell adhesion by ephrins

Scholarly Activities

Member of editorial board: Neuroscience Bulletin; Cell & Bioscience

Membership in: AAAS, Society of Neuroscice, ARVO

Recent Publications

1. Wu, TL, Wang, BN, Yang, AJ, Wang, L, You, YN, Zhou, RQ. C-type lectin 4 of Toxocara canis activates NF-ĸB and MAPK pathways by modulating NOD1/2 and RIP2 in murine macrophages in vitro. Parasitol Res. 2024;123 (4):189. doi: 10.1007/s00436-024-08212-2. PubMed PMID:38639821
2. Wang, W, Zhou, R, Di, S, Mao, X, Huang, WC. Switchable CO₂-Responsive Janus Nanoparticle for Lipase Catalysis in Pickering Emulsion. J Agric Food Chem. 2024; :. doi: 10.1021/acs.jafc.4c00498. PubMed PMID:38639643
3. Li, Z, Wu, WX, Ji, ZX, Zhao, KP, Zhou, RJ, Jiang, S, Li, QZ. The factors influencing the occurrence of post-ischemic stroke depression and its relationship with the burden score of cerebral small vessel disease. Eur Rev Med Pharmacol Sci. 2024;28 (7):2677-2685. doi: 10.26355/eurrev_202404_35896. PubMed PMID:38639507
4. Liu, ZX, Wang, L, Fu, XS, Long, YQ, Zeng, J, Chen, GY, Zhou, RB, Liu, XD. Analysis of quality evaluation and optimal harvest period of Aurantii Fructus from different sources using UHPLC-Q-TOF-MS/MS. Phytochem Anal. 2024; :. doi: 10.1002/pca.3355. PubMed PMID:38639073
5. Cao, P, Peng, R, Yuan, Q, Zhou, R, Ye, M, Zhou, X. Predictors of non-suicidal self-injury in adolescents with depressive disorder: the role of alexithymia, childhood trauma, and body investment. Front Psychol. 2024;15 :1336631. doi: 10.3389/fpsyg.2024.1336631. PubMed PMID:38638510 PubMed Central PMC11024233
6. Li, P, Gao, S, Wang, Y, Zhou, R, Chen, G, Li, W, Hao, X, Zhu, T. Utilising intraoperative respiratory dynamic features for developing and validating an explainable machine learning model for postoperative pulmonary complications. Br J Anaesth. 2024; :. doi: 10.1016/j.bja.2024.02.025. PubMed PMID:38637267
7. Liu, J, Shen, L, Nguyen-Hoang, L, Zhou, Q, Wang, CC, Lu, X, Sahota, D, Chong, KC, Ying, H, Gu, W et al.. Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial. BMJ Open. 2024;14 (4):e074493. doi: 10.1136/bmjopen-2023-074493. PubMed PMID:38631826