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Guofeng You , Ph.D.

Distinguished Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Photo of Guofeng You Ph.D.

Biography

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

  • 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
  • 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
  • 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
  • 2012 NIH Review Panel for COBRE Pilot Project Applications
  • 2012 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
  • 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
  • 2011 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
  • 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
  • 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
  • 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
  • 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

  1. Wang, R, Yang, Y, You, G, Huang, L, Zhou, X, Jiang, S, Shi, H, Wang, G, Zhang, L. Chronic lateral ankle instability using anterior tibiofibular ligament distal fascicle transfer augmentation repair: an anatomical, biomechanical, and histological study. Front Bioeng Biotechnol. 2024;12 :1326036. doi: 10.3389/fbioe.2024.1326036. PubMed PMID:38515619 PubMed Central PMC10955350
  2. Niu, G, You, G, Liu, X. Interactions of hsian-tsao polysaccharide with corn starch to reduce its in vitro digestibility. Int J Biol Macromol. 2024;265 (Pt 1):130951. doi: 10.1016/j.ijbiomac.2024.130951. PubMed PMID:38503373
  3. Xu, L, Zhang, J, Dong, J, Chen, Q, Ma, S, Jiang, J, Zheng, Y, Zhuo, W, Tang, X, Gao, Y et al.. A bibliometric analysis of Kawasaki disease from 1974 to 2022. Heliyon. 2024;10 (5):e27290. doi: 10.1016/j.heliyon.2024.e27290. PubMed PMID:38486756 PubMed Central PMC10937693
  4. Wang, R, You, G, Yin, S, Jiang, S, Wang, H, Shi, H, Zhang, L. Three-dimensional Mapping Analysis of Talus Fractures and Demonstration of Different Surgical Approaches for Talus Fractures. Orthop Surg. 2024; :. doi: 10.1111/os.14033. PubMed PMID:38485459
  5. Wang, R, Huang, L, Jiang, S, You, G, Zhou, X, Wang, G, Zhang, L. Immediate mobilization after repair of Achilles tendon rupture may increase the incidence of re-rupture: a systematic review and meta-analysis of randomized controlled trials. Int J Surg. 2024; :. doi: 10.1097/JS9.0000000000001305. PubMed PMID:38477123
  6. Zhang, M, Hou, J, Xia, J, Wu, J, You, G, Miao, L. The long-term release and particle fracture behaviors of nanoplastics retained in porous media: Effects of surfactants, natural organic matters, antibiotics, and bacteria. Sci Total Environ. 2024;925 :171563. doi: 10.1016/j.scitotenv.2024.171563. PubMed PMID:38460706
  7. Zhang, L, Wang, R, Yang, S, Jiang, S, You, G, Shi, H, Wang, G. Anterior Talofibular Ligament Repair in Combination With Anterior Tibiofibular Ligament Distal Fascicle Transfer for The Treatment of Chronic Lateral Ankle Instability: A Finite Element Analysis. J Foot Ankle Surg. 2024; :. doi: 10.1053/j.jfas.2024.02.001. PubMed PMID:38438102
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