EOHSI

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

• Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
• Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
• Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
• Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
• Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

• Conduct research as described above.
• Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
• Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
• Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

1. Shi, B, Lin, CC, Lee, CJ, Ning, DS, Lin, CC, Zhao, HW, Yang, CS, Deng, SX, Chiu, YJ, Wang, CC et al.. Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats. Front Pharmacol. 2024;15 :1326415. doi: 10.3389/fphar.2024.1326415. PubMed PMID:38606179 PubMed Central PMC11007778
2. Russell-Goldman, E, Baranov, E, Siegmund, S, Yang, CS, Laga, AC, Hanna, J. Epidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features. Virchows Arch. 2024;484 (3):423-427. doi: 10.1007/s00428-024-03785-w. PubMed PMID:38483613
3. Fu, JT, Yang, CJ, Lee, LY, Chen, WP, Chen, YW, Chen, CC, Sun, YT, Yang, CS, Tzeng, SF. Erinacine S, a small active component derived from Hericium erinaceus, protects oligodendrocytes and alleviates mood abnormalities in cuprizone-exposed rodents. Biomed Pharmacother. 2024;173 :116297. doi: 10.1016/j.biopha.2024.116297. PubMed PMID:38394854
4. Yoon, C, Ham, YS, Gil, WJ, Yang, CS. Exploring the potential of Toxoplasma gondii in drug development and as a delivery system. Exp Mol Med. 2024;56 (2):289-300. doi: 10.1038/s12276-024-01165-7. PubMed PMID:38297164 PubMed Central PMC10907749
5. Yang, M, Wu, X, He, Y, Li, X, Yang, L, Song, T, Wang, F, Yang, CS, Zhang, J. EGCG oxidation-derived polymers induce apoptosis in digestive tract cancer cells via regulating the renin-angiotensin system. Food Funct. 2024;15 (4):2052-2063. doi: 10.1039/d3fo03795a. PubMed PMID:38293823
6. Yang, CS, Coopersmith, CM, Lyons, JD. Cell death proteins in sepsis: key players and modern therapeutic approaches. Front Immunol. 2023;14 :1347401. doi: 10.3389/fimmu.2023.1347401. PubMed PMID:38274794 PubMed Central PMC10808706
7. Yang, CS, Zhang, SH. Investigation of dislocation and twinning behavior in HMX under high-velocity impact employing molecular dynamics simulations. J Mol Model. 2024;30 (2):50. doi: 10.1007/s00894-024-05851-1. PubMed PMID:38267739