Andrew Gow Ph.D. » EOHSI Directory

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A B C D E F G H I J K L M N O P R S T U W Y Z

Andrew Gow Ph.D.

Associate Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Address William Levine Hall Room 009 160 Frelinghuysen Road Piscataway NJ 08854 Phone: 732-445-4612 Fax: 732-445-0119
Photo of Andrew Gow Ph.D.

Biographical Info

Education

  • BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
  • MEd,  Temple University, Philadelphia, PA
  • PhD, Temple University, Philadelphia, PA
  • Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

  • S-nitrosylation of pulmonary collectins
  • Role of nitric oxide in lung disease
  • Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

  • 2001, Florence R.C. Murray Fellowship
  • 2000, Translational Medicine Award, Duke University
  • 1998, Chartered Chemist, Royal Society of Chemistry
  • 1997, Young Investigator Award, International Nitric Oxide Society
  • 1996, Young Investigator Award, Oxygen Society
  • 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
  • 1993-95, Russell Conwell Research Fellowship

Recent Publications

  1. Massa, CB, Groves, AM, Jaggernauth, SU, Laskin, DL, Gow, AJ. Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation. PLoS Comput. Biol. 2017;13 (8):e1005570. doi: 10.1371/journal.pcbi.1005570. PubMed PMID:28837561 PubMed Central PMC5570219
  2. Venosa, A, Gow, JG, Hall, L, Malaviya, R, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol. Sci. 2017;157 (1):222-234. doi: 10.1093/toxsci/kfx032. PubMed PMID:28184907
  3. Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
  4. Francis, M, Sun, R, Cervelli, JA, Choi, H, Mandal, M, Abramova, EV, Gow, AJ, Laskin, JD, Laskin, DL. Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol. Sci. 2017;155 (1):182-195. doi: 10.1093/toxsci/kfw192. PubMed PMID:27708193
  5. Theodorou, IG, Ruenraroengsak, P, Gow, A, Schwander, S, Zhang, JJ, Chung, KF, Tetley, TD, Ryan, MP, Porter, AE. Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. Nanotoxicology. 2016;10 (9):1351-62. doi: 10.1080/17435390.2016.1214762. PubMed PMID:27441789 PubMed Central PMC5322737
  6. Seiffert, J, Buckley, A, Leo, B, Martin, NG, Zhu, J, Dai, R, Hussain, F, Guo, C, Warren, J, Hodgson, A et al.. Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats. Respir. Res. 2016;17 (1):85. doi: 10.1186/s12931-016-0407-7. PubMed PMID:27435725 PubMed Central PMC4950697
  7. Sweeney, S, Leo, BF, Chen, S, Abraham-Thomas, N, Thorley, AJ, Gow, A, Schwander, S, Zhang, JJ, Shaffer, MSP, Chung, KF et al.. Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. Colloids Surf B Biointerfaces. 2016;145 :167-175. doi: 10.1016/j.colsurfb.2016.04.040. PubMed PMID:27182651
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Categories: Faculty, Toxicology
Updated 4 months ago.

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