Jeffrey D. Laskin, Ph.D.
Office: EOHSI Room 441
170 Frelinghuysen Road
Department of Environmental & Occupational Medicine
Robert Wood Johnson Medical School
Piscataway, NJ 08854
EOHSI Room 441
170 Frelinghuysen Road
Fax: (732) 445-0119
Professor & Chief, Division of Toxicology
Environmental and Occupational Medicine
Robert Wood Johnson Medical School, Piscataway, NJ
Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ
Rutgers University CounterACT Research Center of Excellence
Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ
Dr. Jeffrey D. Laskin is a Professor and Chief of the Division of Toxicology in the Department of Environmental and Occupational Medicine at Robert Wood Johnson Medical School (RWJMS). He is director of the Toxicology Division at the Environmental and Occupational Health Sciences Institute (EOHSI), a joint program of Rutgers University and RWJMS and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the UMDNJ/Rutgers University CounterACT Research Center of Excellence, a major White House initiated national security priority to expedite research on the most promising scientific discoveries that would lead to improved medical countermeasures to protect Americans against a chemical, biological, radiological, or nuclear (CBRN) attack. He is a member of the NJ Department of Homeland Security Preparedness College and is a founding member of the Executive Committee of the University Center for Disaster Preparedness and Emergency Response of RWJMS-UMDNJ, Rutgers University, and Robert Wood Johnson University Hospital.
Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Graduate School at Rutgers University, the Pharmacology graduate program at Robert Wood Johnson Medical School and the Cancer Institute of New Jersey. Dr. Laskin also serves as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.
Dr. Laskin has served as an editor on over 20 journals that deal with pharmacology, toxicology and cancer research. With over 150 peer-reviewed publications, a book, numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 25 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.
Demonstrated that sulfur mustard induces autophagy in the skin
Developed models for sulfur mustard-induced skin and lung toxicity
Synthesized >100 inhibitors of chemical-induced skin and lung injury
Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes
Founder, New Jersey Basic and Applied Dermatology Forum
NASA, Issues in Advanced Environmental Health and Advanced Food Technology
NIH grant reviewer
Member, Cancer Institute of New Jersey
Member, NJ Department of Homeland Security Preparedness College
Executive Committee, NJ Universities Homeland Security Research Consortium
Executive Committee, University Center for Disaster Preparedness and Emergency Response
Director, Rutgers University CounterACT Research Center of Excellence
Connor AJ, Chen LC, Joseph LB, Laskin JD, Laskin DL. Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4. Exp Mol Pathol. 2013, 94(1):216-227. PMID: 23000425.
Deshmukh M, Kutscher HL, Gao D, Sunil VR, Malaviya R, Vayas K, Stein S, Laskin JD, Laskin DL, Sinko PJ. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release. 2012, 164(1):65-73. PMID: 23041417.
Liu Y, Gardner CR, Laskin JD, Laskin DL. Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol. 2013, 94(1):160-167. PMID: 23103612.
Dragomir AC, Sun R, Choi H, Laskin JD, Laskin DL. Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J Immunol. 2012, 189(12):5934-5941. PMID: 23175698.
Chang YC, Wang JD, Svoboda KK, Casillas RP, Laskin JD, Gordon MK, Gerecke DR. Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol Appl Pharmacol. 2013, 268(2):178-187. PMID: 23357548.
Sunil VR, Vayas KN, Massa CB, Gow AJ, Laskin JD, Laskin DL. Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics. Toxicol Sci. 2013, 133(2):309-319. PMID: 23492811.
Yang S, Jan YH, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 2013, 288(26):19221-19237. PMID: 23640889.
Zheng R, Po I, Mishin V, Black AT, Heck DE, Laskin DL, Sinko PJ, Gerecke DR, Gordon MK, Laskin JD. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol. 2013, 272(2):345-355. PMID: 23845594.
Groves AM, Gow AJ, Massa CB, Hall L, Laskin JD, Laskin DL. Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2013, 305(8):L555-568. PMID: 23997172.
Zheng R, Heck DE, Black AT, Gow A, Laskin DL, Laskin JD. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014, 67:1-9. PMID: 24140437.
Jan YH, Heck DE, Malaviya R, Casillas RP, Laskin DL, Laskin JD. Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling. Chem Res Toxicol. 2014, 27(1):61-75. PMID: 24274902.
Malaviya R, Laskin JD, Laskin DL. Oxidative stress-induced autophagy: role in pulmonary toxicity. Toxicol Appl Pharmacol. 2014, 275(2):145-151. PMID: 24398106
Zheng R, Heck DE, Mishin V, Black AT, Shakarjian MP, Kong AN, Laskin DL, Laskin JD. Modulation of keratinocyte expression of antioxidants by4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol. 2014, 275(2):113-121. PMID: 24423726.
Jan YH, Heck DE, Dragomir AC, Gardner CR, Laskin DL, Laskin JD. Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. 2014, 27(5):882-894. PMID: 24661219.
Joseph LB, Heck DE, Cervelli JA, Composto GM, Babin MC, Casillas RP, Sinko PJ, Gerecke DR, Laskin DL, Laskin JD. Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Exp Mol Pathol. 2014, 96(3):316-327. PMID: 24662110.
Zheng R, Dragomir AC, Mishin V, Richardson JR, Heck DE, Laskin DL, Laskin JD. Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicol Appl Pharmacol. 2014, 279(1):43-52. PMID: 24832492.
Sunil VR, Vayas KN, Cervelli JA, Malaviya R, Hall L, Massa CB, Gow AJ, Laskin JD, Laskin DL. Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation. Exp Mol Pathol. 2014, 97(1):89-98. PMID: 24886962.
Mishin V, Heck DE, Laskin DL, Laskin JD. Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci. 2014, 141(2):344-352. PMID: 25061110.
Chang YC, Wang JD, Hahn RA, Gordon MK, Joseph LB, Heck DE, Heindel ND, Young SC, Sinko PJ, Casillas RP, Laskin JD, Laskin DL, Gerecke DR. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol Appl Pharmacol. 2014, 280(2):236-344. PMID: 25127551.
Guillon CD, Wisnoski DD, Saxena J, Heindel ND, Heck DE, Wolff DJ, Laskin JD. Nω-Nitro-Nω’-Substituted Guanidines: A Simple Class of Nitric Oxide Synthase Inhibitors, Mod Res Inflamm. 2014, 3(2):48-58. PMID: 25360396.
Yang S, Jan YH, Mishin V, Richardson JR, Hossain MM, Heindel ND, Heck DE, Laskin DL, Laskin JD. Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. J Pharmacol Exp Ther. 2014 Dec 30. pii: jpet.114.221572. [Epub ahead of print] PubMed PMID: 25550200.
Malaviya R, Gow AJ, Francis M, Abramova EV, Laskin JD, Laskin DL. Radiation-induced Lung Injury and Inflammation in Mice: Role of Inducible Nitric Oxide Synthase and Surfactant Protein D. Toxicol Sci. 2014 Dec 30. pii: kfu255. [Epub ahead of print] PubMed PMID: 25552309.