1st International Workshop on
Modifiers of Chemical Toxicity:

Implications for Human Health Risk Assessment

 

 

 

Scientific Program

 

Saturday, June 11, 2005
15:00 - 18:00 Registration
   
Sunday, June 12, 2005
10:00 - 12:00 Registration
13:30 - 14:00 Welcome and Introduction
D. Cory-Slechta
E. Marafante
D. Sarigiannis
14:00 - 17:00 Session One: Elaborating the Problem
Canice Nolan, Ph.D. and Denis Sarigiannis, Ph.D., Co-Chairs
  Kenneth Olden, Ph.D.: Genomics in Environmental Health Research - Opportunities and Challenges
 

Deborah Cory-Slechta, Ph.D.: Studying Toxicants as Single Chemicals: Does this Strategy Adequately Identify Neurotoxic Risk?

15:30 – 16:00 Break
   
16:00 – 17:30 Andreas Kortenkamp, Ph.D.: Low-Dose Response of Endocrine Disruptors
 

Mark Hanson, M.D.: Living with the Past: Evolution, Development and Patterns of Disease

 
 
Discussion
17:30 - 19:00 Reception
   

Monday, June 13, 2004
   
09:00 - 11:00 Session Two: Exposure Complexity

Costas Kiparissides, Ph.D. and Erminio Marafante, Ph.D., Co-Chairs

 

Joel Pounds, Ph.D. : Bioavailability as a Confounder and Modifier of Mixture Toxicity

 

Pertti Hakkinen, Ph.D. : Human Exposures to Many Sources of Mixtures as a Part of Daily Life

 

Denis Sarigiannis, Ph.D.: Future needs in modeling complex exposure for Integrated Health Risk Assessment

 

Linda Birnbaum, Ph.D. : Toxic Equivalency Approach for Dioxins: An Example of Dose Additivity

   
11:00-11:30 Break
   
11:30-13:30 Session Three: Case Studies of Exposure Complexity
  Kenneth Olden, Ph.D. and Marie Vahter, Ph.D., Co-Chairs
 

Bruce Blumberg, Ph.D. – New Insights into the Function of the Steroid and Xenobiotic Receptor, SXR

 

Anneclair DeRoos, Ph.D. – Pesticides mixtures and lymphoma

 

Richard Seegal, Ph.D. – Polychlorinated Biphenyls and Methylmercury Alter Neuronal Function

   
13:30-14:30 Lunch

14:30-16:00 Session Four: Intrinsic Risk Modifiers

Peter Helms,M.D., Ph.D. and Andreas Kortenkamp, Ph.D., Co-Chairs

  D.B. Peden, Ph.D. – Environment, Lifestyle, Genetics and Asthma Development
 

Bernard Weiss, Ph.D. – Does Sex Matter? Male Brains, Female Brains, and Environmental Exposures

  Marie Vahter, Ph.D. – Gender Differences in the Disposition and Toxicity of Metals
  Erminio Marafante, Ph.D – Exposure and Physiological Factors Modulating Gene Expression in Tissues of Mice Exposed to Arsenic
   
16:00-16:30

Break

16:30-18:00

Discussion Session

21:00 Dinner

Tuesday, June 14, 2005
   
09:00 - 10:30 Session Five: Extrinsic Risk Modifiers
 

Joel Pounds, Ph.D. and Linda Birnbaum, Ph.D., Co-Chairs

Progressive Risks

 

Mona Thiruchelvam, Ph.D. : Developmental Pesticide Exposure and the Parkinson's Disease Phenotype

  Laura Gribaldo, Ph.D.: Putting the Haematopoietic System to Work for a New Concept of Risk Assessment
 

Peter Helms, M.D., Ph.D.: Age-differentiated Exposure and Respiratory Outcomes

   
10:30 - 11:00 Break
   
11:00 - 13:00

Session Six : Nutrition Modifiers

 

Deborah Cory-Selchta, Ph.D. and Laura Gribaldo, M.D., Co-Chairs

 

Harihara Mehendahlem Ph.D. : Caloric Restriction and Regression of Toxicant-Induced Liver Injury: Molecular Mechanisms

 

James O’Callaghan, Ph.D.: Obesity Exacerbates Neurotoxicity

 

Ronald Hood, Ph.D. – Alteration of Developmental Toxicity by Protein Deficient Maternal Diets and Other Dietary Factors

 

Isabella Annesi-Maesano, Ph.D. : Diet Impact on Lung Diseases

   
13:00 - 14:30 Lunch
   
14:30 - 15:30

Keynote Lecture:
Chris Portier, Ph.D.:Identifying and Quantifying Modifiers of Chemical Toxicity Using New Tools and New Methods

15:30 - 18:00 Session Seven: Posters Presentation and Discussion
  Deborah Cory-Slechta, Ph.D. and Ronald Hood, Ph.D., Co-Chairs
   
21:00

Dinner


Wednesday, June 15, 2005
   
09:00 - 12:00 Session Eight: Roundtable and Discussion
  Kenneth Olden, Ph.D. and Canice Nolan, Ph.D., Summary Remarks and Co-Chairs
   
 

Participants:

 

Andreas Kortenkamp, Ph.D.
Joel Pounds, Ph.D.
Deborah Cory-Slechta, Ph.D.
Erminio Marafante, Ph.D.
Marie Vahter, Ph.D.
Christopher Portier, Ph.D.
Joan Cranmer, Ph.D.
Ronald Hood, Ph.D.

   
 

Denis Sarigiannis, Ph.D. and Linda Birnbaum, Ph.D., Rapporteurs

   
12:00 Conference Closing
   
   


 

Sponsored by

The Joint Research Centre, European Commission, and

The Environmental and Occupational Health Sciences Institute,
UMDNJ-RWJMS

In collaboration with the Centre for Research

and Technology Hellas, Aristotle University of Thessaloniki


For additional information, please contact us at: conference@eohsi.rutgers.edu